Association between Genetic Instability andHelicobacter pyloriInfection in Gastric Epithelial Dysplasia
نویسندگان
چکیده
منابع مشابه
Association between Genetic Instability and Helicobacter pylori Infection in Gastric Epithelial Dysplasia
Background. In gastric carcinogenesis, changes of DNA methylation appear to be an early molecular event, and the genome-wide methylation state is closely correlated with the level of long interspersed nucleotide element-1 (LINE-1) methylation. In this study, we measured LINE-1 methylation level according to genetic instability and evaluated the effect of Helicobacter pylori infection on genetic...
متن کاملGenetic Instability in Gastric Cancer
Gastric cancer remains a worldwide burden as a second leading cause of cancer death in both sexes (Globocan, 2011; Nobili et al., 2011). Although its incidence is in decline in developed countries, it is still the fourth most common malignancy in the world, behind cancers of the lung, breast, colon, and rectum (Globocan, 2011). The fall in its incidence is attributed mainly to the decline of th...
متن کاملEpithelial Dysplasia in Oral Cavity (Review Article)
Among oral lesions, we encounter a series of malignant epithelial lesions that go through clinical and histopathologic processes in order to be diagnosed. Identifying these processes along with the etiology knowledge of these lesions is very important in prevention and early treatments. Dysplasia is the step preceding the formation of squamous cell carcinoma in lesions which have the potential ...
متن کاملGenetic Aspects of Gastric Cancer Instability
Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear. Malignant transformation of gastric cells is the conseque...
متن کاملDiagnostic variation and outcome for high-grade gastric epithelial dysplasia.
HYPOTHESIS High-grade dysplasia (HGD) of the gastric epithelium is associated with high prevalence of invasive carcinoma, and distinction by endoscopic biopsy is difficult. DESIGN Cohort study, 1996 to 2003. SETTING Tertiary care center. PATIENTS Consecutive sample of 22 patients with initial diagnosis of gastric HGD by endoscopic biopsy. Biopsy specimens were separately reviewed by 3 exp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology Research and Practice
سال: 2012
ISSN: 1687-6121,1687-630X
DOI: 10.1155/2012/360929